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Updated: Oct 31, 2025

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
Priapism and Sickle Cell Disease: Special Considerations in Etiology, Management, and Prevention
Geeta Ahuja1, Chukwuka Ibecheozor2, Nnaemeka C Okorie1
1Howard University College of Medicine, Washington, DC.
Abstract:
Sickle cell disease (SCD) is an inherited medical condition where sickled red blood cells cause vaso-occlusive crisis. One major complication of SCD is priapism, defined as an erection of the penis lasting over four hours beyond sexual stimulation or orgasm. SCD priapism is caused by sickled erythrocytes obstructing venous outflow and can lead to permanent erectile dysfunction. This article reviews the pathology, physiology, and management of SCD priapism, including potential novel therapeutic agents.
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