Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

163
Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
163
Factors Affecting Protein-Drug Binding: Protein-Related Factors01:20

Factors Affecting Protein-Drug Binding: Protein-Related Factors

334
Drug binding to proteins is a key aspect of pharmacokinetics and can influence a drug's distribution, absorption, and elimination in the body. Several factors, including the drug's physiochemical properties, protein concentration, disease states, and the number of binding sites on the protein, influence this process.
The physicochemical properties of a drug play a significant role in its ability to bind to proteins. Lipophilic drugs, which dissolve in fats, oils, and lipids, can be...
334
Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

6.3K
The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
6.3K
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

228
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
228
Factors Affecting Protein-Drug Binding: Patient-Related Factors01:29

Factors Affecting Protein-Drug Binding: Patient-Related Factors

164
Protein-drug binding, a pivotal aspect of pharmacokinetics, is subject to considerable variability influenced by an array of patient-related factors. The intricate interplay of age, individual differences, and pathological conditions significantly impact the binding dynamics and subsequent pharmacological effects.
Age stands as a key determinant in protein-drug binding. Neonates, characterized by low albumin content, experience heightened concentrations of unbound drugs such as phenytoin and...
164
Inflammation01:38

Inflammation

56.9K
Overview
56.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intraoperative Metal Detection vs. Preoperative computed tomography for Combat-related Shrapnel Localization: A Cadaveric Comparison.

The Israel Medical Association journal : IMAJ·2026
Same author

Operative benefits of embolisation in advanced-stage juvenile nasopharyngeal angiofibroma: a meta-analytic comparison.

The Journal of laryngology and otology·2026
Same author

Cumulative Cytological Assessment of Repeated Non-Diagnostic Thyroid Fine Needle Aspirations: A Novel Approach to Reduce Diagnostic Uncertainty.

Diagnostic cytopathology·2026
Same author

Association Between Thyroid Gland Volume and Postoperative Hypothyroidism Following Hemithyroidectomy.

OTO open·2026
Same author

Corrigendum to "Decline in emergency department visits during the COVID-19 quarantine." [The American Journal of Emergency Medicine. 71 (2023) 74-80].

The American journal of emergency medicine·2026
Same author

Unveiling Hidden Dangers: A Comprehensive Study of Thyroid Nodules and Malignancy Rates in the Galilee.

The Israel Medical Association journal : IMAJ·2025

Related Experiment Video

Updated: Oct 31, 2025

Isolation of Primary Mouse Hepatocytes for Nascent Protein Synthesis Analysis by Non-radioactive L-azidohomoalanine Labeling Method
08:04

Isolation of Primary Mouse Hepatocytes for Nascent Protein Synthesis Analysis by Non-radioactive L-azidohomoalanine Labeling Method

Published on: October 23, 2018

19.3K

Serum albumin levels and inflammation.

Arik Sheinenzon1, Mona Shehadeh2, Regina Michelis3

  • 1Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.

International Journal of Biological Macromolecules
|June 28, 2021
PubMed
Summary

This study found a negative correlation between albumin and C-reactive protein (CRP) levels in hospitalized patients, indicating lower albumin during inflammation. Further research is needed to explore the underlying mechanisms of this relationship.

Keywords:
AlbuminC-reactive proteinInflammation

More Related Videos

Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1β using a Whole Blood Stimulation Assay
06:29

Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1β using a Whole Blood Stimulation Assay

Published on: March 1, 2011

26.6K
Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
12:50

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

Published on: September 15, 2017

6.7K

Related Experiment Videos

Last Updated: Oct 31, 2025

Isolation of Primary Mouse Hepatocytes for Nascent Protein Synthesis Analysis by Non-radioactive L-azidohomoalanine Labeling Method
08:04

Isolation of Primary Mouse Hepatocytes for Nascent Protein Synthesis Analysis by Non-radioactive L-azidohomoalanine Labeling Method

Published on: October 23, 2018

19.3K
Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1β using a Whole Blood Stimulation Assay
06:29

Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1β using a Whole Blood Stimulation Assay

Published on: March 1, 2011

26.6K
Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
12:50

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

Published on: September 15, 2017

6.7K

Area of Science:

  • Clinical Chemistry
  • Biochemistry
  • Immunology

Background:

  • Albumin is the primary plasma protein, crucial for fluid balance, acid-base homeostasis, and molecular transport.
  • C-reactive protein (CRP) is an acute-phase reactant produced by hepatocytes, serving as a key biomarker for inflammation.
  • Existing knowledge suggests inverse relationships between albumin and acute-phase reactants like CRP during inflammatory states.

Purpose of the Study:

  • To investigate the correlation between serum albumin levels and common inflammatory markers.
  • To assess the relationship between albumin, C-reactive protein (CRP), white blood cell (WBC) count, and platelet (PLT) count in a large patient cohort.
  • To examine these correlations within specific hospital departments.

Main Methods:

  • Retrospective analysis of 4434 hospitalized patients (ages 18-107) at Galilee Medical Center over three months.
  • Statistical assessment of correlations between albumin and CRP, WBC, PLT, and hemoglobin levels.
  • Linear regression analysis to evaluate the effect of CRP on albumin levels.

Main Results:

  • A significant negative correlation was observed between albumin and CRP (r = -0.311) and between albumin and WBC (r = -0.157).
  • Positive correlations were found between albumin and platelets (r = 0.084) and albumin and hemoglobin (r = 0.513).
  • The strongest negative albumin-CRP correlation was in Internal Medicine; CRP had a minor effect on albumin, evident only at very high CRP levels (>500 mg/L).

Conclusions:

  • A notable inverse relationship exists between serum albumin and inflammatory markers, particularly CRP, in hospitalized patients.
  • The findings support the clinical observation of declining albumin during inflammatory processes.
  • Further investigation is warranted to elucidate the specific biological mechanisms driving the inverse correlation between albumin and CRP.