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Role of epigenetic regulation in myocardial ischemia/reperfusion injury

Keyan Wang1, Yiping Li1, Tingting Qiang1

  • 1Cardiovascular Research Institute of Traditional Chinese Medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China,; Cardiovascular Department of Traditional Chinese Medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Branch of National Clinical Research Center for Chinese Medicine Cardiology, Shanghai 201203, China.

Pharmacological Research
|June 28, 2021
PubMed

Insights

Acute myocardial infarction (AMI) treatment can cause reperfusion injury. Epigenetic mechanisms like histone modification and DNA methylation offer new therapeutic targets for preventing this injury.

Area of Science:

  • Cardiovascular Medicine
  • Molecular Biology
  • Epigenetics

Background:

  • Acute myocardial infarction (AMI) is a leading global cause of death.
  • Reperfusion therapy is crucial for AMI but can induce myocardial ischemia/reperfusion injury.
  • Currently, no effective treatments exist for myocardial ischemia/reperfusion injury.

Purpose of the Study:

  • To review the role of epigenetic modifications in myocardial ischemia/reperfusion injury.
  • To explore potential therapeutic targets for mitigating reperfusion injury.
  • To provide insights for future research and clinical interventions.

Main Methods:

  • Literature review focusing on epigenetic mechanisms.
  • Analysis of studies on histone modification, DNA methylation, noncoding RNAs, and m6A methylation.
  • Synthesis of current understanding of epigenetics in myocardial ischemia/reperfusion injury.

Main Results:

  • Epigenetic regulation, including histone modification, DNA methylation, noncoding RNAs, and m6A methylation, is implicated in the pathogenesis of myocardial ischemia/reperfusion injury.
  • These epigenetic changes contribute to the cellular damage and dysfunction following reperfusion.
  • Targeting these epigenetic pathways presents a promising therapeutic strategy.

Conclusions:

  • Epigenetic mechanisms play a significant role in myocardial ischemia/reperfusion injury.
  • Targeting epigenetic modifications offers a novel therapeutic avenue for treating and preventing reperfusion injury after AMI.
  • Further research into these pathways could lead to improved clinical outcomes for AMI patients.

Keywords:
3-bromo-4,5-dihydroxybenzaldehyde (PubChem CID: 8768)5-aza-2’-deoxycytidine (PubChem CID: 451668)AlleviateCurcumin (PubChem CID: 969516)Dihydromyricetin (PubChem CID: 161557)Epigenetic regulationMyocardial ischemia/reperfusion injuryN-acetyl-5-methoxytryptamine (PubChem CID: 896)Suberoylanilide hydroxamic acid (PubChem CID: 5311)Trans sodium crocetinate (PubChem CID: 10287099)Trichostatin A (PubChem CID: 444732)Tubastatin A (PubChem CID: 49850262)

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