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Intestinal permeability in type 1 diabetes: An updated comprehensive overview
Mia Øgaard Mønsted1, Nora Dakini Falck1, Kristina Pedersen1
1The Bartholin Institute, Department of Pathology, Rigshospitalet, Copenhagen N, Denmark.
Journal of Autoimmunity
|June 28, 2021
Summary
Increased intestinal permeability is consistently observed in type 1 diabetes (T1D). This review synthesizes evidence from human and animal studies, highlighting the gut barrier
Area of Science:
- Immunology
- Gastroenterology
- Endocrinology
Background:
- Type 1 diabetes (T1D) etiopathogenesis involves genetic and environmental factors.
- The gastrointestinal (GI) tract is a key interface for environmental influences.
- Barrier defects in the GI tract may allow diabetogenic antigens to trigger beta-cell autoimmunity.
Purpose of the Study:
- To provide a comprehensive overview of intestinal permeability in T1D.
- To analyze findings across various methodologies in human and animal models.
- To identify consistencies and variations in intestinal permeability research in T1D.
Main Methods:
- Review of in vivo and ex vivo permeability studies.
- Analysis of zonulin, molecular permeability, and blood markers.
- Inclusion of data from human patients and animal models of T1D.
Main Results:
- Consistent evidence indicates increased intestinal permeability in T1D.
- Intestinal permeability in animal models varies by age and strain.
- Dietary interventions impacting diabetes incidence also affect intestinal permeability in models.
Conclusions:
- Increased intestinal permeability is a significant factor in T1D development.
- Methodological and experimental design choices are crucial in T1D permeability studies.
- A strong association exists between heightened intestinal permeability and T1D pathogenesis.
Keywords:
Barrier integrityIntestinal permeabilityLeaky gutParacellular permeabilityTranscellular permeabilityType 1 diabetesMore Related Videos
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