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Role of the Prognostic Nutritional Index in Patients With Soft-tissue Sarcoma
Yumi Matsuyama1, Tomoki Nakamura2, Keisuke Yoshida1
1Department of Orthopedic Surgery, Mie University Graduate School of Medicine, Tsu, Japan.
Background:
This study aimed to determine whether the prognostic nutritional index (PNI) can predict the prognosis in patients with soft-tissue sarcoma (STS) before treatment and to examine whether there is an association between PNI values and clinical characteristics.
Patients And Methods:
The data on 100 patients with primary STS were retrospectively reviewed. The cohort included 55 men and 45 women, with a mean age of 64 years. The mean follow-up duration was 41.7 months.
Results:
The median PNI was 51.35. The PNI was significantly inversely associated with tumor size, tumor grade, and age. We found that the PNI was a significant prognostic marker for disease-specific and event-free survival using univariate and multivariate analyses. Patients with a low PNI had poorer disease-specific and event-free survival than those with a high PNI.
Conclusion:
These results suggest that the PNI can be used as a prognostic marker in patients with STS.
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