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Expression of LAT1 and 4F2hc in Gastroenteropancreatic Neuroendocrine Neoplasms
Yosuke Horita1, Kyoichi Kaira2, Tomonori Kawasaki3
1Department of Gastroenterological Oncology, International Medical Center, Saitama Medical University, Saitama, Japan; york01@saitama-med.ac.jp.
Background/Aim:
Little is known about the expression of L-type amino acid transporter 1 (LAT1) and 4F2hc in gastroenteropancreatic-neuroendocrine neoplasms (GEP-NENs). Hence, we conducted a study to verify the clinicopathological significance of LAT1 and 4F2hc.
Patients And Methods:
Tissues from 126 patients with GEP-NENs were collected between August 2007 and August 2019 at our institution. We evaluated LAT1 and 4F2hc expression by immunohistochemistry, and examined their clinical significance.
Results:
No statistically significant associations were observed between LAT1 expression and the different NENs. Expression of 4F2hc was significantly different between neuroendocrine tumour (NET)-G1, NET-G2, and NET-G3 (p=0.029), and was significantly associated with vascular invasion (p=0.044) and the Ki-67 index (p=0.042).
Conclusion:
No association between LAT1 expression and malignant features in GEP-NENs was observed. However, an association between 4F2hc expression and the potential of malignancy in GEP-NENs was evident.
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