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Updated: Oct 31, 2025

Author Spotlight: Development of a Smartphone-Enhanced Paper-Based Device for Rapid Dengue NS1 Detection

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Published on: January 26, 2024

Dengue vaccine: an update.

Chung-Hao Huang^1,2, Yu-Te Tsai^1,3,4, Seng-Fan Wang^4,5

¹Division of Infectious Disease, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.

Expert Review of Anti-Infective Therapy

|June 29, 2021

Summary

Dengue vaccine development shows progress, but challenges remain. New strategies like prime-boost regimens show promise, yet efficacy and safety, especially in naïve populations, require further research.

Keywords:

DNA vaccine Dengue virus dengue vaccine heterologous prime/boost inactivated virus live-attenuated virus subunit vaccine

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Last Updated: Oct 31, 2025

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A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

Area of Science:

Virology
Immunology
Vaccinology

Background:

Dengue virus poses a significant global health burden, causing millions of infections annually.
Current dengue vaccines face limitations in efficacy and safety profiles, particularly in specific populations.

Purpose of the Study:

To review recent advancements in dengue vaccine development up to December 2020.
To summarize findings from published literature and clinical trials.

Main Methods:

Literature review of dengue vaccine research.
Analysis of data from ClinicalTrials.gov.

Main Results:

The first tetravalent dengue vaccine (CYD-TDV) is licensed but shows variable efficacy and safety concerns in dengue-naïve individuals.
Heterologous prime-boost regimens, combining different vaccine types, demonstrate potential for improved immunogenicity and reduced risk of antibody-dependent enhancement (ADE).

Conclusions:

Dengue vaccine development is ongoing, with novel prime-boost strategies showing promise.
Overcoming challenges such as the lack of ideal animal models, like the macaque model, is crucial for future progress.