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High density lipoprotein cholesterol and longevity.

A Keys1

  • 1Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis.

Journal of Epidemiology and Community Health
|March 1, 1988
PubMed
Summary
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High density lipoprotein cholesterol (HDL) levels in middle-aged men did not predict overall longevity. However, lower HDL was associated with coronary heart disease (CHD) mortality, suggesting a link to specific causes of death.

Area of Science:

  • Cardiovascular epidemiology
  • Biomarkers of disease
  • Longitudinal cohort studies

Background:

  • The Twin Cities Prospective Study tracked healthy executive men aged 45-55 from 1948 to 1975.
  • Serum high density lipoprotein cholesterol (HDL) was measured in 1955.
  • Follow-up extended to 1983, with comprehensive mortality data.

Purpose of the Study:

  • To investigate the relationship between serum HDL cholesterol and long-term mortality in middle-aged men.
  • To determine if HDL levels predict all-cause mortality, coronary heart disease (CHD), or cancer mortality.
  • To explore associations between HDL, body fatness, blood pressure, and other risk factors.

Main Methods:

  • Serum HDL cholesterol analysis using standardized methods.

Related Experiment Videos

  • Longitudinal follow-up of a cohort of 217 men for mortality outcomes.
  • Statistical analyses including multiple regression and logistic regression.

    • Main Results:

    • No significant difference in mean HDL between survivors and those who died from all causes.
    • Men who died from coronary heart disease (CHD) had lower HDL compared to survivors and those who died from neoplasms.
    • HDL was negatively correlated with body fatness and positively related to age at death from CHD.

    Conclusions:

    • Serum HDL cholesterol in middle age does not appear to be a predictor of overall longevity.
    • Lower HDL levels may be associated with increased risk of death from coronary heart disease (CHD).
    • HDL cholesterol's relationship with mortality is complex and may be cause-specific.