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Related Experiment Video

Updated: Oct 31, 2025

A Reference Broth Microdilution Method for Dalbavancin In Vitro Susceptibility Testing of Bacteria that Grow Aerobically

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Published on: September 9, 2015

Antimicrobial defined daily dose in neonatal population.

Cristina Villanueva-Bueno¹, Elena Montecatine-Alonso¹, Francisco Jiménez-Parrilla²

¹Department of Pharmacy, Institute of Biomedicine of Seville (IBIS), Hospital Universitario Virgen del Rocío, Sevilla, Spain.

Enfermedades Infecciosas Y Microbiologia Clinica (English Ed.)

|June 29, 2021

Summary

A new method for measuring antimicrobial consumption in neonates was developed, addressing limitations of the standard defined daily dose (DDD). This approach can improve antimicrobial stewardship in neonatal intensive care units.

Keywords:

Antimicrobial consumption Consumo de antimicrobianos Neonatal antimicrobial prescription Neonatology Neonatología Prescripción de antimicrobianos en neonatos

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Last Updated: Oct 31, 2025

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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

Area of Science:

Neonatal pharmacology
Infectious disease epidemiology
Drug utilization research

Background:

The standard defined daily dose (DDD) metric for antimicrobial consumption has limitations for neonatal patients.
Accurate measurement of antimicrobial use in neonates is crucial for effective stewardship.

Purpose of the Study:

To propose and describe an alternative method for calculating antimicrobial DDD specifically for neonatal populations.
To establish a reliable metric for monitoring antimicrobial consumption in neonatal intensive care units.

Main Methods:

A novel DDD calculation method was designed for neonates (<1 month old) across six Spanish hospitals.
Data collected included neonate weight and gestational age; DDD was calculated using weight, recommended dose, and common infectious indications determined by the Delphi method.

Main Results:

The study included 4820 neonates, with a mean gestational age of 36.72 weeks and mean weight of 2.687 kg.
Standardized DDD values (intravenous; oral) were calculated for numerous antimicrobials, including amoxicillin (0.08; 0.08), cefotaxime (0.27), and vancomycin (0.08; 0.11).

Conclusions:

A practical method for measuring antimicrobial DDD in neonatology has been established.
This method can aid in monitoring antimicrobial consumption in hospital settings and should be validated for future use in neonatal antimicrobial stewardship programs.