HOTAIR beyond repression: In protein degradation, inflammation, DNA damage response, and cell signaling

Area of Science:

• Molecular Biology
• Epigenetics
• Genomics

Background:

• Long noncoding RNAs (lncRNAs) are key regulators of cellular functions.
• HOX transcript antisense intergenic RNA (HOTAIR) is a known epigenetic regulator implicated in diseases.
• Emerging evidence suggests HOTAIR has functions beyond gene silencing.

Purpose of the Study:

• To summarize the diverse functions of HOTAIR.
• To explore HOTAIR's roles in protein degradation, inflammation, DNA repair, and disease.
• To provide a comprehensive overview of HOTAIR's mechanisms of action.

Main Methods:

• Literature review of recent studies on HOTAIR.
• Analysis of experimental data on HOTAIR functions.
• Synthesis of information on HOTAIR's involvement in various biological processes.

Main Results:

• HOTAIR participates in protein degradation pathways.
• HOTAIR influences inflammatory and immune signaling.
• HOTAIR plays a role in DNA damage response.
• HOTAIR is implicated in a broader range of diseases than previously understood.

Conclusions:

• HOTAIR exhibits multifaceted roles extending beyond its canonical function as a repressor lncRNA.
• Understanding these diverse functions is crucial for comprehending HOTAIR's involvement in disease pathogenesis.
• Further research into HOTAIR's novel functions may reveal new therapeutic targets.