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Immunometabolism: A 'Hot' Switch for 'Cold' Pediatric Solid Tumors

Lin Xiao1, Harrison Yeung2, Michelle Haber1

  • 1Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, NSW 2052, Australia; School of Women's and Children's Health, University of New South Wales Sydney, Randwick, NSW 2052, Australia.

Trends in Cancer
|June 29, 2021
PubMed

Insights

Pediatric solid tumors evade immune attack, hindering immunotherapy. Targeting tumor metabolism offers a novel strategy to enhance immunotherapy effectiveness in children with solid cancers.

Area of Science:

  • Oncology
  • Immunology
  • Metabolic pathways

Background:

  • Immunotherapies show success in adult cancers and pediatric blood cancers, but not pediatric solid tumors.
  • Pediatric solid tumors possess mechanisms to evade the immune system, limiting current immunotherapy efficacy.
  • Altered tumor metabolism is a key factor in immune evasion within pediatric solid tumors.

Purpose of the Study:

  • To review metabolic alterations in pediatric solid tumors that promote immune escape.
  • To discuss novel strategies targeting these metabolic pathways.
  • To explore the potential of combining metabolic targeting with immunotherapy for pediatric solid cancers.

Main Methods:

  • Literature review of metabolic pathways in pediatric solid tumors.
  • Analysis of current antimetabolic strategies.
  • Exploration of potential therapeutic combinations and translational challenges.

Main Results:

  • Pediatric solid tumors exhibit specific metabolic reprogramming that supports immune evasion.
  • Targeting these metabolic pathways presents a promising avenue for overcoming immunotherapy resistance.
  • Combination of antimetabolic strategies with immunotherapies could enhance treatment efficacy.

Conclusions:

  • Metabolic reprogramming in pediatric solid tumors is a critical target for improving immunotherapy outcomes.
  • Novel antimetabolic strategies hold potential for potentiating immunotherapies in pediatric solid cancers.
  • Further research and preclinical testing are needed to translate these findings into clinical applications, particularly through personalized medicine approaches.
Keywords:
immune coldimmunometabolismimmunotherapypediatric solid tumors

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