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Related Experiment Video

Updated: Oct 31, 2025

Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells
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Syphilitic meningitis presenting with multiple cranial neuropathies.

Melissa Chu1, Shejil Kumar2, Jonathan Sturm3

  • 1Gosford Hospital, Gosford, New South Wales, Australia.

BMJ Case Reports
|June 29, 2021
PubMed
Summary

Early neurosyphilis, a challenging diagnosis, can present with cranial neuropathies. Prompt treatment with benzylpenicillin led to rapid recovery in a patient with syphilitic meningitis, highlighting the importance of considering syphilis in neurological cases.

Keywords:
cranial nervesinfection (neurology)meningitisneuroimagingsyphilis

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Area of Science:

  • Neurology
  • Infectious Diseases
  • Ophthalmology

Background:

  • Syphilis is a growing public health concern.
  • Neurosyphilis diagnosis and treatment are complicated by its diverse symptoms.
  • Early syphilitic meningitis can manifest subtly, posing diagnostic challenges.

Observation:

  • A case of early syphilitic meningitis presented with multiple cranial neuropathies.
  • Cerebrospinal fluid (CSF) analysis revealed inflammation with significant lymphocytosis.
  • The patient was diagnosed with neurosyphilis using both serum and CSF tests.

Findings:

  • Intravenous benzylpenicillin therapy resulted in a swift resolution of neurological deficits.
  • The case underscores the varied presentations of neurosyphilis.

Implications:

  • Neurosyphilis should be suspected in immunocompetent individuals with unexplained cranial neuropathies.
  • Early diagnosis and treatment are crucial for favorable neurological outcomes.
  • Increased awareness of neurosyphilis is vital for clinicians managing neurological disorders.