Related Experiment Video
Updated: Oct 31, 2025
13:24
Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies
Published on: April 11, 2016
12.0K
Challenges adopting next-generation sequencing in community oncology practice
Fredrick D Ashbury1,2,3, Keith Thompson1,4,5, Casey Williams6,7
1VieCure, Denver, Colorado, USA.
Current Opinion in Oncology
|June 29, 2021
Summary
Innovative cancer genomics tools optimize drug selection and development. Addressing individual, institutional, and societal challenges is crucial for integrating these advancements into routine oncology care and improving patient outcomes.
Area of Science:
- Cancer genomics
- Oncology
- Precision medicine
Background:
- Cancer genomics innovations offer new ways to reduce cancer's impact.
- Genomic characterization of tumors guides drug development and treatment decisions.
Purpose of the Study:
- To review the challenges in adopting cancer genomics in community oncology.
- To propose strategies for overcoming these barriers to improve patient outcomes.
Main Methods:
- Review of literature on cancer genomics.
- Analysis of authors' experience in community oncology practice.
Main Results:
- Barriers to cancer genomics implementation exist at individual, institutional, and societal levels.
- Next-generation tumor sequencing is becoming essential for clinical decisions.
Conclusions:
- Effective coordination is needed for the adoption and delivery of cancer genomics.
- Addressing identified challenges is key to improving patient outcomes through genomic-guided oncology.
More Related Videos
Related Concept Videos
03:00Next-generation Sequencing
95.0K
The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
95.0K
01:57Sanger Sequencing
763.4K
DNA sequencing is a fundamental technique that is routinely used in the biological sciences. This method can be applied to a range of questions at different scales - from the sequencing of a cloned DNA fragment or the study of a mutation in a gene up to whole-genome sequencing. However, despite the widespread use of sequencing today, it was not until 1977 that Fredrick Sanger and his collaborators developed the chain-termination method to decode DNA sequences. It relies on the separation of a...
763.4K
03:21RNA-seq
10.8K
RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases.
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
10.8K