Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Diabetes Mellitus: Overview and Type I Subtype

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

HR-pQCT reveals marked trabecular and cortical structural deficits in women with pregnancy and lactation-associated osteoporosis (PLO).

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2024

Same author

Enzymatic and Non-enzymatic Collagen Cross-Links and Fracture Occurrence in Type 1 Diabetes Patients.

Calcified tissue international·2024

Same author

An evaluation of COVID-19 vaccine messaging platforms in the emergency department.

Academic emergency medicine : official journal of the Society for Academic Emergency Medicine·2024

Same author

Quantitative Trait Loci Mapping for Bacterial Wilt Resistance and Plant Height in Tomatoes.

Plants (Basel, Switzerland)·2024

Same author

Bone intrinsic material and compositional properties in postmenopausal women diagnosed with long-term Type-1 diabetes.

Bone·2023

Same author

Osteocyte lacunae in transiliac bone biopsy samples across life span.

Acta biomaterialia·2022

Same journal

EDITORIAL INTRODUCTION.

Current opinion in endocrinology, diabetes, and obesity·2026

Same journal

Exploring the role of parathyroid hormone in sarcopenia: A review.

Current opinion in endocrinology, diabetes, and obesity·2026

Same journal

Normocalcemic primary hyperparathyroidism: an update on diagnostic and management challenges.

Current opinion in endocrinology, diabetes, and obesity·2026

Same journal

Prediabetes before pregnancy: implications for risk stratification and research.

Current opinion in endocrinology, diabetes, and obesity·2026

Same journal

Secondary hyperparathyroidism in chronic kidney disease: update on pathophysiology and new treatment targets.

Current opinion in endocrinology, diabetes, and obesity·2026

Same journal

Revisiting the relationship between weight loss and bone health in people living with obesity: insights from the latest evidence.

Current opinion in endocrinology, diabetes, and obesity·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Oct 31, 2025

A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes

A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes

Published on: February 17, 2023

Future studies using histomorphometry in type 1 diabetes mellitus.

Laura A Graeff-Armas¹, Emily Silverman¹, Robert R Recker²

¹Department of Diabetes, Endocrinology & Metabolism, University of Nebraska Medical Center.

Current Opinion in Endocrinology, Diabetes, and Obesity

|June 29, 2021

Summary

This summary is machine-generated.

This review examines type 1 diabetes (T1DM) and bone health, highlighting low bone turnover as a key factor in fragility. Further research using human bone biopsies is needed to understand the mechanisms.

More Related Videos

Staining Protocols for Human Pancreatic Islets

Staining Protocols for Human Pancreatic Islets

Published on: May 23, 2012

Computational Reconstruction of Pancreatic Islets as a Tool for Structural and Functional Analysis

Computational Reconstruction of Pancreatic Islets as a Tool for Structural and Functional Analysis

Published on: March 9, 2022

Related Experiment Videos

Last Updated: Oct 31, 2025

A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes

A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes

Published on: February 17, 2023

Staining Protocols for Human Pancreatic Islets

Staining Protocols for Human Pancreatic Islets

Published on: May 23, 2012

Computational Reconstruction of Pancreatic Islets as a Tool for Structural and Functional Analysis

Computational Reconstruction of Pancreatic Islets as a Tool for Structural and Functional Analysis

Published on: March 9, 2022

Area of Science:

Endocrinology
Metabolic Bone Disease
Diabetes Research

Background:

Bone fragility is a significant complication in type 1 diabetes (T1DM).
Bone turnover markers have historically been used to assess bone status in various diseases, including diabetes.
Limited human bone histomorphometry data exists for T1DM.

Purpose of the Study:

To review the current research on human bone turnover markers and histomorphometry in type 1 diabetes.
To highlight recent findings on the acute effects of insulin and exercise on bone turnover.
To discuss the role of low bone turnover in T1DM-related bone fragility.

Main Methods:

Review of recent literature on human bone turnover markers.
Analysis of new studies on dynamic testing of bone turnover.
Examination of available human bone histomorphometry data in T1DM.

Main Results:

Low bone turnover is implicated as a primary factor in bone fragility in T1DM.
New studies explore dynamic testing conditions for bone turnover, including effects of insulin and exercise.
Few human bone histomorphometry studies are published, with more currently in progress.

Conclusions:

Low bone turnover is a potential mechanism contributing to bone fragility in type 1 diabetes.
Further investigation using human transilial bone biopsies is crucial for elucidating underlying mechanisms.
Continued research in bone histomorphometry is essential for understanding bone health in T1DM.