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Published on: November 13, 2016
Relationship between Tumor Necrosis Factor-Alpha and Neuropeptide Y Expression and Neurological Function Score in
Li Qiu1, Dongli Zhang1, Yan Sang1
1Department of Neurology (II), Xuzhou Children's Hospital, Xuzhou Medical University, Xuzhou, 221006, P.R.China.
Insights
Tumor Necrosis Factor-alpha (TNF-α) and Neuropeptide Y (NPY) are elevated in epileptic children. These biomarkers correlate with poorer neurological function scores, indicating their potential role in epilepsy progression.
Area of Science:
- Neuroscience
- Immunology
- Pediatrics
Background:
- Epilepsy in children is a significant neurological disorder.
- Understanding biomarkers associated with disease severity is crucial.
Purpose of the Study:
- To investigate the relationship between Tumor Necrosis Factor-alpha (TNF-α) and Neuropeptide Y (NPY) expression and neurological function in epileptic children.
Main Methods:
- Serum levels of TNF-α and NPY were measured using ELISA in 54 epileptic children and 30 healthy controls.
- Neurological function was assessed using the National Institute of Health stroke scale (NIHSS) and Hamilton Anxiety (HAMA) scores.
Main Results:
- Epileptic children showed significantly higher serum levels of TNF-α and NPY compared to controls (P<0.001).
- Both TNF-α and NPY levels positively correlated with NIHSS and HAMA scores (P<0.001).
Conclusions:
- Elevated TNF-α and NPY expression are observed in epileptic children.
- These elevated biomarkers are positively associated with neurological dysfunction in pediatric epilepsy.
Background:
To observe the relationship between Tumor Necrosis Factor-alpha (TNF-α) and Neuropeptide Y (NPY) expression and neurological function score in epileptic children.
Methods:
Fifty-four epileptic children diagnosed and treated in Xuzhou Children's Hospital, China from Feb 2017 to Mar 2018 were collected and included in a research group (RG), while 30 healthy children who underwent physical examination at the same time were included in the control group (CG). ELISA was used to detect the expression of TNF-α and NPY in the serum of children in the two groups, and those before treatment were compared. The National Institute of Health stroke scale (NIHSS) and Hamilton Anxiety (HAMA) scores before and after treatment were observed, and Pearson correlation was used to analyze the relationship between the expression levels of TNF-α and NPY in the serum as well as NIHSS and HAMA scores.
Results:
The expression levels of TNF-α and NPY in the serum of children in the RG were significantly higher than those in the CG (P<0.001). The expression level of TNF-α was positively correlated with the NIHSS and HAMA scores (r=0.748, P<0.001) (r=0.772, P<0.001). The expression level of NPY was positively correlated with the NIHSS and HAMA scores (r=0.768, P<0.001) (r=0.643, P<0.001).
Conclusion:
TNF-α and NPY are highly expressed in epileptic children and are positively correlated with neurological function score.
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