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In-Hospital 30-Day Survival Among Young Adults With Coronavirus Disease 2019: A Cohort Study

Safiya Richardson1,2, Jordan Gitlin2, Zachary Kozel2

  • 1Institute of Health System Science, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York, USA.

Open Forum Infectious Diseases
|June 29, 2021
PubMed

Insights

Obesity is a significant risk factor for mortality in young adults hospitalized with COVID-19. This study identified obesity and comorbidity scores as key predictors of 30-day survival in this demographic.

Area of Science:

  • Infectious Diseases
  • Epidemiology
  • Public Health

Background:

  • Young adults (18-39 years) are increasingly hospitalized with COVID-19.
  • Understanding risk factors for severe outcomes in this population is crucial.

Purpose of the Study:

  • To characterize young adults hospitalized with COVID-19.
  • To identify predictors of 30-day in-hospital mortality in this age group.

Main Methods:

  • Retrospective cohort study of 1013 patients aged 18-39 hospitalized with COVID-19.
  • Data extracted from electronic health records across 12 NYC acute care hospitals.
  • Analysis focused on demographic, clinical data, and 30-day survival outcomes.

Main Results:

  • The majority of patients (92.8%) survived hospitalization.
  • Obesity (51.2%) was the most common comorbidity.
  • Obesity (aHR, 2.71) and Charlson comorbidity index (aHR, 1.20) independently predicted higher mortality risk.

Conclusions:

  • Obesity is the strongest negative predictor of 30-day survival in young adults with COVID-19.
  • Comorbidity burden also significantly impacts survival outcomes.
Abstract

Keywords:
coronavirus disease 2019 (COVID-19)mortalitysevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)young adults

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