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Disturbed Interhemispheric Functional and Structural Connectivity in Type 2 Diabetes.

Ying Cui1, Tian-Yu Tang2, Chun-Qiang Lu1

  • 1Department of Radiology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.

Journal of Magnetic Resonance Imaging : JMRI
|June 29, 2021
PubMed
Summary

Type 2 diabetes mellitus (T2DM) disrupts brain connectivity, particularly in the lingual gyrus. Insulin resistance is linked to these changes, suggesting it as a target for cognitive impairment interventions.

Keywords:
cognitive impairmentdeterministic tractographyinsulin resistanceinterhemispheric coordinationtype 2 diabetes mellitusvoxel-mirrored homotopic connectivity

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Area of Science:

  • Neuroimaging
  • Endocrinology
  • Neurology

Background:

  • Type 2 diabetes mellitus (T2DM) is linked to cognitive decline and brain alterations.
  • Interhemispheric coordination in T2DM patients remains poorly understood.

Purpose of the Study:

  • Investigate interhemispheric functional and anatomic connectivity in T2DM.
  • Examine associations with cognitive performance and endocrine parameters.

Main Methods:

  • Used 3.0T MRI, including resting-state fMRI and diffusion tensor imaging.
  • Calculated Voxel-Mirrored Homotopic Connectivity (VMHC) and analyzed fiber integrity (FA, MD, length).
  • Performed correlational analyses between connectivity, cognition, and endocrine markers.

Main Results:

  • T2DM patients showed decreased VMHC in the lingual gyrus and sensorimotor cortex.
  • Lingual gyrus fibers in T2DM patients had lower fractional anisotropy (FA) and shorter length.
  • Lingual fiber FA correlated negatively with insulin resistance (IR) in T2DM patients.

Conclusions:

  • T2DM is associated with disrupted interhemispheric coordination, affecting both functional and anatomical connectivity.
  • Insulin resistance may be a key factor in T2DM-related cognitive impairment, indicating a potential therapeutic target.