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Temporal changes of cardiac acoustic biomarkers and cardiac function in acute decompensated heart failure

Jun Shitara1, Takatoshi Kasai1,2,3, Nobutaka Murata4

  • 1Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.

ESC Heart Failure
|June 29, 2021
PubMed

Insights

Temporal changes in cardiac acoustic biomarkers (CABs) reflect improved heart function in acute decompensated heart failure (ADHF) patients. These CABs show promise for monitoring ADHF status and guiding treatment.

Area of Science:

  • Cardiology
  • Biomedical Engineering
  • Heart Failure Research

Background:

  • Cardiac acoustic biomarkers (CABs) measured by acoustic cardiography have shown associations with clinical outcomes in heart failure (HF) patients.
  • Previous research has not explored the dynamic changes of CABs in relation to evolving HF status.

Purpose of the Study:

  • To investigate if temporal changes in CABs correlate with alterations in cardiac function and status among patients with acute decompensated heart failure (ADHF).

Main Methods:

  • Prospective enrollment of 60 ADHF patients.
  • Collection of CABs (electromechanical activation time, QoS2, S3, S4 intensities) and echocardiography data at admission, pre-discharge, and first clinic visit.
  • Analysis of temporal trends and correlations between CABs and echocardiographic parameters.

Main Results:

  • Significant decreases in electromechanical activation time corrected for RR interval (EMATc), S3 intensity, and S4 intensity from admission to discharge (P < 0.001 for S3/S4, P = 0.001 for EMATc).
  • Significant increase in QoS2 from admission to discharge (P = 0.005).
  • S3 intensity changes correlated with E/A ratio (ρ = 0.571, P < 0.001); extended QoS2 correlated with stroke volume index (ρ = 0.383, P = 0.004).

Conclusions:

  • Certain CABs demonstrate significant, favorable directional changes during ADHF treatment.
  • These evolving CABs may serve as valuable biomarkers for ADHF management and monitoring.
  • Acoustic cardiography offers a promising non-invasive tool for assessing dynamic changes in cardiac function during HF exacerbations.
Abstract

Keywords:
Acoustic cardiographyCardiac acoustic biomarkersHeart failureHeart sound

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