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Updated: Oct 31, 2025

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Palladium-Catalyzed C-H Silylation of Aliphatic Ketones Using an Aminooxyamide Auxiliary
1School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094, China.
Abstract:
A palladium-catalyzed β-C(sp3)-H silylation of aliphatic ketones with disilanes to afford β-silyl ketones is reported. The aminooxyamide auxiliary is critical for the C-H activation and silylation. The reaction tolerates a number of functional groups and shows good selectivity in silylating β-C(sp3)-H bonds in the company of C(sp2)-H bonds and acidic α-C(sp3)-H bonds. The reaction is scalable, and the aminooxyamide auxiliary is readily removed to give β-silyl ketones, which could serve as useful building blocks for organic synthesis. Late-stage diversification using this protocol is demonstrated in the silylation of santonin with good yield.
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