CAR-based cell therapy: evaluation with bibliometrics and patent analysis

Area of Science:

• Biomedicine
• Immunotherapy
• Biotechnology

Background:

• Chimeric antigen receptors (CARs)-based cell therapies have revolutionized biomedicine with significant preclinical and clinical success.
• The scientific and inventive landscape, international cooperation, and research prestige of CARs have not been thoroughly explored.

Purpose of the Study:

• To analyze the bibliometric and patent landscape of CARs research.
• To assess publication metrics, subject areas, research hotspots, patent filing trends, and global contributions.

Main Methods:

• Bibliometric analysis of 5,681 publications.
• Machine learning-based text mining for research hotspots.
• Analysis of 5,010 Inpadoc families for patent trends and rankings.

Main Results:

• CARs research exhibits high prestige within the scientific community.
• Significant global geographical bias observed in both academic output and patenting.
• Strong science-invention links are evident, with notable country-specific variations.
• An inverse relationship exists between country size and international collaboration rates.

Conclusions:

• CARs research is characterized by high prestige, geographical concentration, and robust science-invention connections.
• International collaboration patterns in CARs research are influenced by country size.
• The findings provide insights into the global dynamics of CARs research and development.