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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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The Mammary Tumor Microenvironment.

Colleen S Curran1, Suzanne M Ponik2,3

  • 1Critical Care Medicine Department, Clinical Center, NIH, Bethesda, MD, USA.

Advances in Experimental Medicine and Biology
|June 29, 2021
PubMed
Summary
This summary is machine-generated.

The tumor microenvironment (TME) and extracellular matrix (ECM) density significantly influence breast cancer progression. Understanding cell-ECM interactions in the TME may reveal new therapeutic targets and biomarkers for breast cancer.

Keywords:
Breast cancerCollagenDormancyMammographic densityMechanotransductionMetabolismMetastasisMigrationTumor immunityTumor-associated collagen signatures (TACS)

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Area of Science:

  • Oncology
  • Cell Biology
  • Biochemistry

Background:

  • The tumor microenvironment (TME) comprises immune cells, fibroblasts, adipocytes, and endothelial/epithelial cells within an extracellular matrix (ECM).
  • Breast tissue density is a key factor influencing cell-ECM interactions and biochemical signaling.
  • These interactions regulate critical tumor behaviors like growth, metabolism, immunity, and invasion.

Purpose of the Study:

  • To explore the complex interplay between the extracellular matrix (ECM) and cells within the tumor microenvironment (TME).
  • To review models that mimic ECM density and their utility in understanding breast cancer.
  • To highlight the significance of structural patterns generated by cell-ECM organization in disease progression.

Main Methods:

  • Discussion of the cellular and structural components of the TME.
  • Review of various experimental models designed to mimic ECM density.
  • Analysis of how ECM density affects cellular functions and tumor characteristics.

Main Results:

  • Cell-ECM interactions within the TME are crucial for regulating tumor growth, metabolism, immunity, and invasion.
  • ECM density influences key aspects of breast cancer, including tumorigenesis and dormancy.
  • Distinct structural patterns arise from cell-ECM organization, providing insights into disease development.

Conclusions:

  • Continued investigation into cell-ECM interactions in the TME is essential for advancing breast cancer research.
  • Understanding these interactions may lead to the identification of novel biomarkers and therapeutic targets for breast cancer.
  • Mimicking ECM density in models offers a valuable approach to studying breast cancer biology.