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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells
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Seminal Vesicle Tumor Microenvironment.

Alessia Cimadamore1, Rodolfo Montironi1, Sergio Serni2,3

  • 1Institute of Pathological Anatomy and Histopathology, Polytechnic University of the Marche Region (Ancona), Ancona, Italy.

Advances in Experimental Medicine and Biology
|June 29, 2021
PubMed
Summary
This summary is machine-generated.

Primary seminal vesicle (SV) diseases are rare. Seminal vesicles provide a tumor microenvironment that stimulates prostate cancer growth and invasion, leading to higher rates of metastasis.

Keywords:
AdenocarcinomaBenign tumorsCancer-associated fibroblastsCystadenomaExperimental modelsExtracellular matrixMESTMalignant tumorsMesenchymal tumorsMicroenvironmentMixed epithelial and stromal tumorsMyofibroblastsProstate cancerSeminal vesiclesTumorigenesis

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Area of Science:

  • Urology
  • Oncology
  • Pathology

Background:

  • Primary seminal vesicle (SV) diseases are rare, with seminal vesicle adenocarcinoma being the most common primary tumor.
  • SVs are often involved by tumors from adjacent organs, including prostate, urothelial, and rectal adenocarcinomas.
  • Mesenchymal tumors of the SV include benign lesions like cystadenoma and mixed epithelial and stromal tumors (MESTs).

Purpose of the Study:

  • To investigate the role of the seminal vesicle microenvironment (SVME) in prostate cancer (PCa) progression.
  • To compare the influence of SVME versus the prostate microenvironment on PCa aggressiveness and metastasis.

Main Methods:

  • In vivo experiments using NOD/SCID mice models.
  • Injection of PC3 prostate cancer cells into the prostate versus the seminal vesicles.
  • Evaluation of tumor aggressiveness and incidence of retroperitoneal lymph node metastases.

Main Results:

  • Seminal vesicles offer a tumor microenvironment that stimulates PCa growth and invasion.
  • Mice models with PCa cells injected into SVs exhibited significantly higher rates of retroperitoneal lymph node metastases compared to those injected into the prostate.
  • SVME promotes greater tumor aggressiveness than the prostatic microenvironment.

Conclusions:

  • The seminal vesicle microenvironment significantly enhances prostate cancer progression and metastatic potential.
  • SVs play a crucial role in promoting the growth and invasion of prostate cancer cells.
  • Targeting the SV microenvironment may represent a novel therapeutic strategy for prostate cancer management.