Predicting circRNA-Disease Associations Based on Deep Matrix Factorization with Multi-source Fusion

Recently, circRNAs with covalently closed loops have been discovered to play important parts in the progression of diseases. Nevertheless, the study of circRNA-disease associations is highly dependent on biological experiments, which are time-consuming and expensive. Hence, a computational approach to predict circRNA-disease associations is urgently needed. In this paper, we presented an approach that is based on deep matrix factorization with multi-source fusion (DMFMSF). In DMFMSF, several useful circRNA and disease similarities were selected and then combined by similarity kernel fusion. Then, linear and non-linear characteristics were mined using singular value decomposition (SVD) and deep matrix factorization to infer potential circRNA-disease associations. Performance of the proposed DMFMSF on two benchmark datasets are rigorously validated by leave-one-out cross-validation(LOOCV) and fivefold cross-validation (5-fold CV). The experimental results showed that DMFMSF is superior over several existing computational approaches. In addition, five important diseases, hepatocellular carcinoma, breast cancer, acute myeloid leukemia, colorectal cancer, and coronary artery disease were applied in case studies. The results suggest that DMFMSF can be used as an accurate and efficient computational tool for predicting circRNA-disease associations.