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Application of Vinamidinium Salt Chemistry for a Palladium Free Synthesis of Anti-Malarial MMV048: A "Bottom-Up"
Dinesh J Paymode1, Le Chang2, Dan Chen2
1Medicines for All Institute, 737 North Fifth Street, Box 980100, Richmond, Virginia 23298, United States.
Organic Letters
|June 29, 2021
Abstract:
MMV390048 (1) is a clinical compound under investigation for antimalarial activity. A new synthetic route was developed which couples two aromatic fragments while forming the central pyridine ring over two steps. This sequence takes advantage of raw materials used in the existing etoricoxib supply chain and eliminates the need for palladium catalysts, which were projected to be major cost-drivers.
