Status Toward the Implementation of Precision Dosing in Children

Area of Science:

• Pharmacology and Clinical Pharmacy
• Pediatric Drug Development
• Health Services Research

Background:

• Precision dosing is moving from concept to practice, with increased investment and clinical services.
• Pediatric populations critically need precision dosing due to reliance on adult data and limited pediatric studies.
• Current implementation faces challenges in governance, sustainability, and demonstrating clinical/economic value.

Purpose of the Study:

• To review current pediatric precision dosing efforts, evaluating their utility, longevity, and sustainability.
• To assess the implementation process, identify barriers, and outline stakeholder engagement for broader adoption.
• To emphasize the need for evolving approaches beyond traditional pharmacokinetic-centric models.

Main Methods:

• Literature review of current pediatric precision dosing initiatives.
• Analysis of implementation strategies, including governance and sustainability models.
• Evaluation of barriers to widespread adoption and required stakeholder involvement.

Main Results:

• Precision dosing services are increasing, but pediatric applications lag due to data gaps.
• Sustainability and demonstrating return on investment (ROI) are significant challenges.
• A need exists to consider diverse approaches, including pharmacogenetic data, for pediatric dosing.

Conclusions:

• Pediatric precision dosing requires robust governance, scientific evolution, and outcome data for sustainability.
• Overcoming implementation barriers necessitates collaboration among diverse stakeholders.
• Future efforts should integrate advanced data, including pharmacogenetics, for optimized pediatric dosing.