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Association between perinatal depression and risk of attention deficit hyperactivity disorder among children: a

Nichole L Nidey1, Allison M Momany2, Lane Strathearn3

  • 1Cincinnati Children's Hospital Medical Center, Division of Biostatistics and Epidemiology, Cincinnati, Ohio; Cincinnati Children's Hospital Medical Center, Division of Developmental and Behavioral Pediatrics, Cincinnati, Ohio; Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio.

Annals of Epidemiology
|June 29, 2021
PubMed

Insights

Maternal perinatal depression significantly increases a child's risk of developing attention deficit hyperactivity disorder (ADHD). Early intervention for maternal depression may help mitigate ADHD risks in children.

Area of Science:

  • Perinatal mental health
  • Child developmental disorders
  • Epidemiology

Background:

  • Perinatal depression is a known risk factor for offspring attention deficit hyperactivity disorder (ADHD).
  • Population-based studies are crucial for understanding the link between perinatal depression and ADHD.
  • A 5-year follow-up period was used to examine this association.

Purpose of the Study:

  • To investigate the association between perinatal depression and the risk of ADHD in children.
  • To provide data for targeted interventions for at-risk mothers and children.

Main Methods:

  • Utilized a population-based cohort of privately insured mother-child pairs in Iowa.
  • Employed adjusted Cox proportional-hazard models to estimate hazard ratios.
  • Included 5,635 mother-child pairs in the analysis.

Main Results:

  • 484 mothers were diagnosed with perinatal depression.
  • 269 children were diagnosed with ADHD.
  • Children of mothers with perinatal depression were over three times more likely to be diagnosed with ADHD (HR 3.16).

Conclusions:

  • Maternal perinatal depression is associated with an increased risk of ADHD in offspring.
  • Intervention efforts for maternal depression and ADHD screening/treatment are recommended for this population.
  • Findings support the need for integrated care approaches for maternal mental health and child development.
Abstract

Keywords:
Antenatal depressionAttention-deficit/hyperactivity disorderPostpartum depression

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