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Sjögren's syndrome in progressive systemic sclerosis.

A A Drosos1, A P Andonopoulos, J S Costopoulos

  • 1Department of Medicine, University of Ioannina, School of Medicine, Greece.

The Journal of Rheumatology
|June 1, 1988
PubMed
Summary

Sjögren

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Area of Science:

  • Rheumatology and Immunology
  • Autoimmune Diseases
  • Ophthalmology and Otolaryngology

Background:

  • Progressive systemic sclerosis (PSS) is an autoimmune disease affecting connective tissues.
  • Coexistent autoimmune conditions, like Sjögren's syndrome (SS), can complicate PSS management.
  • Early diagnosis of coexistent SS is crucial for comprehensive patient care.

Purpose of the Study:

  • To determine the prevalence of Sjögren's syndrome (SS) in patients with progressive systemic sclerosis (PSS).
  • To characterize the clinical and serological features of SS in the context of PSS.
  • To investigate the diagnostic utility of labial salivary gland biopsy and specific symptoms.

Main Methods:

  • Prospective evaluation of 44 unselected PSS patients.
  • Diagnosis of SS based on labial salivary gland (LSG) biopsy (focal lymphocytic infiltration ≥2+), keratoconjunctivitis sicca (KCS), and/or xerostomia.
  • Assessment of LSG biopsy scores, parotid flow rates, and anti-Ro (SSA) antibody presence.

Main Results:

  • A 20.5% prevalence of SS was found in PSS patients (9 out of 10 with LSG score ≥2+).
  • Parotid gland enlargement was more common in PSS patients with SS (44.4%).
  • Anti-Ro (SSA) antibodies were detected in 33.3% of SS patients.

Conclusions:

  • Sjögren's syndrome is a common comorbidity in progressive systemic sclerosis.
  • SS in scleroderma patients may present with subtle exocrine gland symptoms but shares clinical and serological similarities with primary SS.
  • LSG biopsy is a valuable tool for diagnosing coexistent SS in PSS.

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