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Invasive lobular carcinoma: clinicopathological features and subtypes
Sabine Danzinger1, Nora Hielscher1, Miriam Izsó1
1Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria.
The Journal of International Medical Research
|June 30, 2021
Summary
Invasive lobular carcinoma (ILC) often presents as grade 2, hormone receptor-positive, and higher stage tumors compared to invasive ductal carcinoma (IDC). Luminal A ILC shows increased lymph node involvement.
Area of Science:
- Oncology
- Pathology
- Breast Cancer Research
Background:
- Invasive lobular carcinoma (ILC) and invasive ductal carcinoma (IDC) are distinct breast cancer subtypes.
- Understanding their differing characteristics is crucial for effective treatment strategies.
Purpose of the Study:
- To compare the clinicopathological features of ILC and IDC.
- To determine the influence of histological type on axillary lymph node (ALN) involvement in luminal A breast cancer.
Main Methods:
- Retrospective analysis of 493 early-stage breast cancer patients (82 ILC, 411 IDC) diagnosed between 2012-2016.
- Surgical cases were reviewed for tumor characteristics and ALN status.
Main Results:
- ILC tumors were more frequently grade 2, estrogen receptor-positive (ER+), had lower proliferation (Ki67 <14%), and higher pathological T stage (pT2-4) than IDC.
- Luminal A subtype was more prevalent in ILC.
- Multivariate analysis linked grade 2, ER+, progesterone receptor-positive, pT2, and pT3 to ILC.
- Luminal A ILC demonstrated significantly higher ALN involvement (pN1-3) compared to luminal A IDC.
Conclusions:
- Grade 2, positive hormone receptor status, and advanced pathological T stage are associated with ILC.
- ILC within the luminal A subtype exhibits a higher frequency of axillary lymph node involvement compared to IDC.
