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Related Concept Videos

Vitamins01:30

Vitamins

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Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
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Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants01:18

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Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
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Connective Tissue Cell Types01:22

Connective Tissue Cell Types

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Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
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Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

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The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
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Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

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The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
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Mineral, Vitamin and Water Absorption01:27

Mineral, Vitamin and Water Absorption

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Electrolytes are essential minerals and ions primarily obtained from the diet and absorbed through the gastrointestinal tract. Most electrolytes are absorbed in the small intestine. While the absorption of iron and calcium primarily occurs in the duodenum, calcium is also absorbed in the jejunum and ileum. In these regions, passive diffusion contributes to its absorption alongside active transport mechanisms in the duodenum. These ions can exit the enterocytes through specialized active...
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Related Experiment Video

Updated: Oct 31, 2025

A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells
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ALSUntangled #62: vitamin C.

Richard Bedlack1, Paul Barkhaus2, Greg Carter3

  • 1Department of Neurology, Duke University, Durham, NC, USA.

Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration
|June 30, 2021
PubMed
Summary
This summary is machine-generated.

Vitamin C is a popular supplement for Amyotrophic Lateral Sclerosis (ALS). Despite theoretical benefits, a human trial found no improvement, so it is not recommended as an ALS treatment.

Keywords:
Vitamin Cacorbic acidascorbateclinical trialsmodelstherapy

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Area of Science:

  • Neuroscience
  • Biochemistry
  • Clinical Trials

Background:

  • Vitamin C is frequently used by patients with Amyotrophic Lateral Sclerosis (ALS).
  • Its antioxidant properties suggest a potential mechanism for slowing ALS progression.
  • Preliminary studies and case reports have indicated possible benefits, though often with methodological limitations.

Purpose of the Study:

  • To evaluate the efficacy of Vitamin C as a treatment for Amyotrophic Lateral Sclerosis (ALS).

Main Methods:

  • A small-scale human clinical trial was conducted to assess Vitamin C's impact on ALS.
  • The study design and specific metrics for assessing benefit were not detailed in the abstract.

Main Results:

  • The human trial yielded negative results, indicating no observed benefit from Vitamin C supplementation in ALS patients.
  • Existing pre-clinical data and case reports suggesting efficacy were considered insufficient or flawed.

Conclusions:

  • Based on the negative clinical trial findings, Vitamin C is not currently advised as a treatment for Amyotrophic Lateral Sclerosis (ALS).
  • Further research may be needed, but current evidence does not support its use.