Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

106
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
106
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

48
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
48
Urine Studies I: Urinalysis01:29

Urine Studies I: Urinalysis

474
Urinalysis is a widely used diagnostic test that analyzes urine's physical, chemical, and microscopic characteristics. Healthcare providers use it to detect and monitor various health conditions, including renal disease, urinary tract infections (UTIs), diabetes, and metabolic or systemic disorders.Components of UrinalysisUrinalysis consists of three primary components: physical, chemical, and microscopic examination. Each provides unique insights into the urine sample and, by extension, the...
474
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

162
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
162
Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

163
Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
163
Imaging Studies II: Ultrasonography01:24

Imaging Studies II: Ultrasonography

101
IntroductionUltrasonography, or renal ultrasound, is a noninvasive medical imaging technique that uses high-frequency sound waves to visualize the kidneys, ureters, bladder, and surrounding tissues.Indications for Urinary System UltrasonographyUrinary system ultrasonography is indicated in various clinical scenarios, such as:Kidney Stones (Urolithiasis): To detect and monitor the size and presence of kidney or urinary tract stones.Hydronephrosis: To assess the dilation of the renal pelvis and...
101

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Proteomic profile of urinary extracellular vesicles from rats with lithium-induced nephrogenic diabetes insipidus.

American journal of physiology. Cell physiology·2026
Same author

Defining the vascular niche of human adipose tissue across metabolic states.

Nature metabolism·2026
Same author

Kidney kallikrein-1 contributes to cleavage of γ-ENaC in vivo.

American journal of physiology. Renal physiology·2026
Same author

Excess dietary potassium raises blood pressure in male mice by an aldosterone-dependent increase in ENaC.

Communications biology·2025
Same author

Sex differences in renal acid-base regulation.

American journal of physiology. Renal physiology·2025
Same author

Deletion of the prostaglandin EP4 receptor in the kidney tubule of mature mice alters kidney water handling only in males.

American journal of physiology. Renal physiology·2025

Related Experiment Video

Updated: Oct 31, 2025

Proteomic Profile of EPS-Urine through FASP Digestion and Data-Independent Analysis
14:48

Proteomic Profile of EPS-Urine through FASP Digestion and Data-Independent Analysis

Published on: May 8, 2021

7.3K

Urinary proteomics for kidney dysfunction: insights and trends.

Qi Wu1, Robert A Fenton1

  • 1Department of Biomedicine, Aarhus University, Aarhus, Denmark.

Expert Review of Proteomics
|June 30, 2021
PubMed
Summary
This summary is machine-generated.

Urinary proteomics offers a promising approach for early kidney disease detection and progression prediction. This advanced technique analyzes urinary biomarkers to identify kidney dysfunction before clinical symptoms arise.

Keywords:
Chronic kidney diseaseexosomekidneykidney dysfunctionproteomicsurinary extracellular vesicleurinary proteomicsurine

More Related Videos

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

409
Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes
11:47

Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes

Published on: March 4, 2022

2.4K

Related Experiment Videos

Last Updated: Oct 31, 2025

Proteomic Profile of EPS-Urine through FASP Digestion and Data-Independent Analysis
14:48

Proteomic Profile of EPS-Urine through FASP Digestion and Data-Independent Analysis

Published on: May 8, 2021

7.3K
Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

409
Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes
11:47

Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes

Published on: March 4, 2022

2.4K

Area of Science:

  • Nephrology
  • Biomarker Discovery
  • Proteomics

Background:

  • Kidney dysfunction presents a significant global health challenge.
  • Early detection and accurate prediction of disease progression are critical unmet needs.
  • Current clinical parameters have limitations in assessing kidney function changes.

Purpose of the Study:

  • To review advances in urinary proteomics for kidney dysfunction.
  • To discuss the role of urinary extracellular vesicles in kidney disease research.
  • To highlight technological progress in urinary proteomic analysis.

Main Methods:

  • Literature search for 'proteomics' and 'urinary' studies within the last 5 years.
  • Manual filtering of retrieved literature for kidney dysfunction relevance.
  • Synthesis of findings on urinary proteomics applications and technological advancements.

Main Results:

  • Urinary proteomics can reveal early molecular alterations in the kidney.
  • Urinary extracellular vesicles are a valuable source for studying kidney dysfunction.
  • Technological innovations are enhancing the capabilities of urinary proteomics.

Conclusions:

  • Urinary proteomics holds significant prognostic potential for kidney dysfunction.
  • Despite advances, clinical application of urinary proteomics is limited.
  • Future developments in proteomics will likely improve kidney disease insights beyond current methods.