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A review of thromboembolic events in hospitalized COVID-19 patients

Paul Fontelo1, Mrigendra M Bastola2, Zhaonian Zheng2

  • 1Applied Clinical Informatics Branch, Lister Hill National Center for Biomedical Communications, National Library of Medicine, National Institutes of Health, 8600 Rockville Pike, Bethesda, MD, 20894, USA. pfontelo@nih.gov.

Thrombosis Journal
|June 30, 2021
PubMed

Insights

COVID-19 patients face a significantly higher risk of developing thromboembolic disorders. This meta-analysis confirms an increased likelihood of these events in hospitalized COVID-19 individuals.

Area of Science:

  • Medical Research
  • Infectious Diseases
  • Cardiovascular Health

Background:

  • Thromboembolic disorders have been frequently observed in COVID-19 patients globally.
  • Existing clinical reports indicate a heightened incidence of these events.

Purpose of the Study:

  • To quantitatively assess the risk of thromboembolic disorders in COVID-19 patients.
  • To synthesize evidence from existing cohort studies through meta-analysis.

Main Methods:

  • A meta-analysis was conducted on data from 19 cohort studies.
  • Studies were selected from PubMed, focusing on COVID-19 patients with diagnosed thromboembolic events.
  • Weighted fixed and random effects models were employed for data analysis.

Main Results:

  • The pooled likelihood of developing thromboembolic disorders among hospitalized COVID-19 patients was found to be 0.28 (95% CI 0.21-0.36).
  • This indicates a substantial risk elevation compared to non-COVID-19 populations.

Conclusions:

  • The study validates a significantly increased risk of venous thromboembolism (VTE) in COVID-19 patients.
  • Findings are crucial for healthcare providers and researchers managing COVID-19 patients.
  • Highlights the importance of monitoring and managing thrombotic risk in this population.
Abstract

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