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Published on: December 14, 2014
Smoking, alcohol and coffee consumption and pregnancy loss: a Mendelian randomization investigation
Shuai Yuan1, Jin Liu2, Susanna C Larsson3
1Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Objective:
To determine the associations of smoking and alcohol and coffee consumption with pregnancy loss.
Design:
Mendelian randomization study.
Setting:
The UK Biobank study and FinnGen consortium.
Patients:
A total of 60,565 cases with pregnancy loss and 130,687 noncases from UK Biobank and 3,312 cases with pregnancy loss and 64,578 noncases from FinnGen.
Intervention(S):
None.
Mains Outcome Measure:
Pregnancy loss.
Result(S):
Genetic predisposition to smoking initiation was associated with an increased risk of pregnancy loss in both UK Biobank and FinnGen. The combined odds ratio (OR) was 1.31 (95% confidence interval [CI], 1.25-1.37) for one standard deviation increase in the prevalence of smoking initiation. There were no significant associations of genetically predicted consumption of alcohol (OR, 1.09; 95% CI, 0.93-1.27) or coffee (OR, 0.96; 95% CI, 0.87-1.06) with pregnancy loss.
Conclusion(S):
This study on the basis of genetic data suggests the causal potential of the association of smoking but not moderate alcohol and coffee consumption with pregnancy loss.
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