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Updated: Oct 31, 2025

Detection of Polyfunctional T Cells in Children Vaccinated with Japanese Encephalitis Vaccine via the Flow Cytometry Technique
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Detection of Polyfunctional T Cells in Children Vaccinated with Japanese Encephalitis Vaccine via the Flow Cytometry Technique

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Kawasaki disease in an infant after administration of hexavalent vaccine

Meshal Z Almeshary1, Saud A Alanazi1, Khalid M Almoosa1

  • 1From the Department of Pediatrics, King Saud University Medical City, Riyadh, Kingdom of Saudi Arabia.

Saudi Medical Journal
|June 30, 2021
PubMed

Insights

Kawasaki disease, a rare condition in children, involves blood vessels. A case study suggests a possible, though unproven, link between hexavalent vaccines and this condition in infants.

Area of Science:

  • Pediatric Vascular Medicine
  • Immunology and Vaccine Safety

Background:

  • Kawasaki disease is a leading cause of acquired heart disease in children, characterized by inflammation of medium-sized arteries.
  • The etiology of Kawasaki disease remains unknown, prompting investigation into potential environmental triggers.
  • Concerns exist regarding a potential association between childhood vaccinations and Kawasaki disease, necessitating careful evaluation.

Observation:

  • This report details a case of incomplete Kawasaki disease in a 4-month-old infant occurring shortly after hexavalent vaccination.
  • The infant presented with significant dilatation of all coronary arteries, a major complication of Kawasaki disease.

Findings:

  • The temporal association between hexavalent vaccination and the onset of incomplete Kawasaki disease and coronary artery dilatation was noted.
  • No definitive causal link or increased risk of Kawasaki disease following vaccination has been established in current scientific literature.

Implications:

  • While this case highlights a rare possibility, current evidence does not support a causal relationship between vaccines and Kawasaki disease.
  • Further research and surveillance are warranted to thoroughly investigate potential adverse effects and understand the multifactorial etiology of Kawasaki disease.

Keywords:
hexavalent vaccineinfantkawasaki disease

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