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Updated: Aug 3, 2026
An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
Published on: December 10, 2013
Experimental Models for SARS-CoV-2 Infection
Taewoo Kim1,2, Jeong Seok Lee3,2, Young Seok Ju1,3
1Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea.
Abstract:
Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) is a novel virus that causes coronavirus disease 2019 (COVID-19). To understand the identity, functional characteristics and therapeutic targets of the virus and the diseases, appropriate infection models that recapitulate the in vivo pathophysiology of the viral infection are necessary. This article reviews the various infection models, including Vero cells, human cell lines, organoids, and animal models, and discusses their advantages and disadvantages. This knowledge will be helpful for establishing an efficient system for defense against emerging infectious diseases.
Insights
Understanding SARS-CoV-2 requires effective infection models. This review examines various models like cell lines, organoids, and animals, highlighting their pros and cons for COVID-19 research and future disease defense.
Area of Science:
- Virology
- Infectious Diseases
- Pathophysiology
Background:
- Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) causes COVID-19.
- Understanding viral mechanisms and identifying therapeutic targets necessitates accurate infection models.
Purpose of the Study:
- To review and analyze diverse SARS-CoV-2 infection models.
- To discuss the advantages and disadvantages of each model for recapitulating in vivo pathophysiology.
Main Methods:
- Review of existing literature on Vero cells, human cell lines, organoids, and animal models for SARS-CoV-2 infection.
- Comparative analysis of model systems based on their ability to mimic in vivo viral infection.
Main Results:
- Various models (Vero cells, human cell lines, organoids, animal models) exist for studying SARS-CoV-2.
- Each model possesses unique strengths and limitations in replicating the disease's in vivo characteristics.
Conclusions:
- Selection of appropriate infection models is crucial for advancing COVID-19 research.
- Knowledge of model systems aids in developing effective strategies against emerging infectious diseases.
