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Updated: Oct 31, 2025

Production of a SARS-CoV-2 Virus-Like-Particle System to Investigate Viral Life Cycles In Vitro

Production of a SARS-CoV-2 Virus-Like-Particle System to Investigate Viral Life Cycles In Vitro

Published on: June 6, 2025

Experimental Models for SARS-CoV-2 Infection.

Taewoo Kim^1,2, Jeong Seok Lee^3,2, Young Seok Ju^1,3

¹Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea.

Molecules and Cells

|June 30, 2021

Summary

This summary is machine-generated.

Understanding SARS-CoV-2 requires effective infection models. This review examines various models like cell lines, organoids, and animals, highlighting their pros and cons for COVID-19 research and future disease defense.

Keywords:

COVID-19 SARS-CoV-2 coronavirus infection model organoid

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An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

Published on: December 10, 2013

Area of Science:

Virology
Infectious Diseases
Pathophysiology

Background:

Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) causes COVID-19.
Understanding viral mechanisms and identifying therapeutic targets necessitates accurate infection models.

Purpose of the Study:

To review and analyze diverse SARS-CoV-2 infection models.
To discuss the advantages and disadvantages of each model for recapitulating in vivo pathophysiology.

Main Methods:

Review of existing literature on Vero cells, human cell lines, organoids, and animal models for SARS-CoV-2 infection.
Comparative analysis of model systems based on their ability to mimic in vivo viral infection.

Main Results:

Various models (Vero cells, human cell lines, organoids, animal models) exist for studying SARS-CoV-2.
Each model possesses unique strengths and limitations in replicating the disease's in vivo characteristics.

Conclusions:

Selection of appropriate infection models is crucial for advancing COVID-19 research.
Knowledge of model systems aids in developing effective strategies against emerging infectious diseases.