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Related Experiment Video

Updated: Oct 31, 2025

Synergetic Use of Neural Precursor Cells and Self-assembling Peptides in Experimental Cervical Spinal Cord Injury

Synergetic Use of Neural Precursor Cells and Self-assembling Peptides in Experimental Cervical Spinal Cord Injury

Published on: February 23, 2015

Facilitated and Controlled Strontium Ranelate Delivery Using GCS-HA Nanocarriers Embedded into PEGDA Coupled with

Chih-Wei Chiang^1,2, Chih-Hwa Chen^3,4,5,6, Yankuba B Manga⁴

¹Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, 10617, Taiwan.

International Journal of Nanomedicine

|June 30, 2021

Summary

This study developed a novel strontium ranelate (SrR) nanoformulation for spinal bone regeneration. The new formulation enhanced bone healing in animal models, offering a promising alternative to oral SrR for osteoporosis treatment.

Keywords:

drug formulation glycol chitosan hyaluronic acid nanoparticles strontium ranelate

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Last Updated: Oct 31, 2025

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Published on: February 23, 2015

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Area of Science:

Biomaterials Science
Regenerative Medicine
Drug Delivery Systems

Background:

Oral strontium ranelate (SrR) is an osteoporosis treatment with limited clinical use due to side effects.
Developing safer and more effective delivery systems for SrR is crucial for bone regeneration.

Purpose of the Study:

To formulate and characterize a novel nano-carrier system for strontium ranelate (SrR).
To evaluate the efficacy of the developed SrR nanoformulation for spinal bone regeneration.

Main Methods:

SrR nanoparticles (SrRNPs) were encapsulated in glycol chitosan-hyaluronic acid nanoformulations.
SrRNPs were further embedded in poly(ethylene glycol) diacrylate hydrogels (SrRNPs-H).
Characterization involved SEM, TEM, FTIR, DLS, and rheometry; biocompatibility and efficacy were assessed using osteoblast and rat spinal decortication models.

Main Results:

In vitro cytotoxicity tests confirmed SrRNPs are non-toxic to osteoblasts.
In vivo studies on rat models demonstrated enhanced bone regeneration with SrRNPs-H compared to control groups.
Radiographical and histological analyses confirmed superior new bone formation.

Conclusions:

The novel SrR nanoformulation (SrRNPs-H) shows significant potential for spinal bone regeneration.
Local administration of this formulated SrR offers a promising alternative to oral administration for bone defect treatment.