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Glioblastoma Multiforme Masquerading as Stroke.

William Remley1, Nitin Butala2

  • 1Neurology, Lake Erie College of Osteopathic Medicine, Jacksonville, USA.

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Summary

Sudden anomic aphasia, typically acute, can mask chronic brain tumors. This case highlights a glioblastoma presenting as a focal neurological deficit, emphasizing the need to consider chronic causes for acute symptoms.

Keywords:
anomicaphasiaeegglioblastomagliomamultiformetemporaltumor

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Area of Science:

  • Neurology
  • Neuro-oncology
  • Neuroscience

Background:

  • Sudden-onset anomic aphasia often suggests acute neurological events like stroke.
  • Focal neurological deficits require thorough etiological investigation.

Observation:

  • A 68-year-old female presented with acute anomic aphasia.
  • Initial stroke evaluation was negative, prompting further neuroimaging.

Findings:

  • Magnetic resonance imaging revealed a left temporal lobe lesion.
  • Electroencephalogram indicated epileptic activity in the left temporal lobe.
  • Biopsy confirmed World Health Organization grade IV glioblastoma.

Implications:

  • This case underscores that chronic conditions, such as brain tumors, can manifest with acute neurological symptoms.
  • It highlights the importance of comprehensive diagnostic workups for sudden-onset neurological deficits.
  • Considering underlying chronic pathologies is crucial even with seemingly acute presentations.