Hesperidin Modulates Troponin-1 Serum Level and Decrease Heart Tissue Injury of Irradiated Rats

Area of Science:

• Radiotherapy
• Cardiology
• Pharmacology

Background:

• The heart is a critical dose-limiting organ in mediastinal radiotherapy.
• Radiation-induced cardiac injury is a significant clinical concern.

Purpose of the Study:

• To evaluate the radioprotective effects of Hesperidin (HES), a natural flavonoid.
• To investigate HES's impact on cardiac injury following localized mediastinal irradiation in rats.

Main Methods:

• Sixty male rats were divided into four groups: Sham, Hesperidin only, Radiation, and Radiation+HES.
• HES was administered orally for seven days prior to irradiation.
• Cardiac injury markers (troponin-1) and histopathological changes were assessed post-irradiation.

Main Results:

• Irradiation significantly increased serum troponin-1 levels and induced cardiac inflammation, pericardial effusion, and vascular plaque formation.
• Hesperidin administration significantly reduced troponin-1 levels and ameliorated the observed histopathological damage.

Conclusions:

• Hesperidin demonstrates significant radioprotective effects against cardiac injury induced by mediastinal irradiation.
• Oral HES administration prior to radiotherapy may mitigate radiation-induced cardiac toxicity.