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Clinical Features and Outcomes of Streptococcus anginosus Group Infective Endocarditis: A Multicenter Matched Cohort

Francesc Escrihuela-Vidal1, Luis Eduardo López-Cortés2, Laura Escolà-Vergé3,4

  • 1Department of Infectious Diseases, Hospital Universitari de Bellvitge, Institut d´Investigació Biomèdica de Bellvitg e, University of Barcelona, Barcelona, Spain.

Open Forum Infectious Diseases
|June 30, 2021
PubMed

Insights

Streptococcus anginosus group (SAG) endocarditis is uncommon but serious, with outcomes similar to viridans group streptococci (VGS) or Streptococcus gallolyticus group (SGG) endocarditis. This study found no significant differences in complications or mortality between SAG and VGS/SGG infections.

Area of Science:

  • Infectious Diseases
  • Cardiology
  • Microbiology

Background:

  • Streptococcus anginosus group (SAG) endocarditis is often presumed severe, linked to abscesses and emboli.
  • Limited evidence currently supports the severity assumption for SAG endocarditis.

Purpose of the Study:

  • To evaluate the clinical presentation and outcomes of SAG endocarditis.
  • To compare SAG endocarditis with viridans group streptococci (VGS) and Streptococcus gallolyticus group (SGG) endocarditis.

Main Methods:

  • Retrospective analysis of prospectively collected data from 72 patients with definite SAG endocarditis.
  • Matched comparison (1:2) with 144 patients with VGS or SGG endocarditis across 28 centers in Spain and Italy.

Main Results:

  • SAG endocarditis was community-acquired, frequently affecting the aortic native valve.
  • No significant differences were observed in septic shock, valve disorders, paravalvular complications, heart failure, or embolic events between SAG and VGS/SGG groups.
  • Surgical indications and mortality rates were similar between the SAG and VGS/SGG groups.

Conclusions:

  • SAG endocarditis is an infrequent but serious condition.
  • The prognosis of SAG endocarditis is comparable to that of VGS/SGG endocarditis.
Abstract

Keywords:
Streptococcus anginosusStreptococcus gallolyticusinfective endocarditisviridans group streptococci

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