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Published on: November 6, 2020
IL-7 Immunotherapy in a Nonimmunocompromised Patient With Intractable Fungal Wound Sepsis
Isaiah R Turnbull1, Monty B Mazer2,3, Mark H Hoofnagle1
1Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.
Abstract:
A nonimmunocompromised patient developed life-threatening soft tissue infection with Trichosporon asahii, Fusarium, and Saksenaea that progressed despite maximum antifungal therapies and aggressive debridement. Interleukin-7 immunotherapy resulted in clinical improvement, fungal clearance, reversal of lymphopenia, and improved T-cell function. Immunoadjuvant therapies to boost host immunity may be efficacious in life-threatening fungal infections.
