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Updated: Oct 31, 2025

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

Atypical core-periphery brain dynamics in autism.

Dipanjan Roy¹, Lucina Q Uddin²

¹Cognitive Brain Dynamics Lab, National Brain Research Centre, Manesar, India.

Network Neuroscience (Cambridge, Mass.)

|June 30, 2021

Summary

This summary is machine-generated.

Human brain dynamics involve core-periphery interactions across timescales, impacting behavior. This review examines autism, focusing on atypical brain network dynamics and sensory-cognitive profiles using time-resolved fMRI.

Keywords:

Atypical timescales Caudate Core and contextual symptom severity Core-periphery dynamics Restricted and repetitive behaviors Sensory-motor network

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Published on: December 7, 2018

Area of Science:

Neuroscience
Cognitive Science
Developmental Psychology

Background:

The human brain exhibits dynamic intrinsic functions across multiple timescales.
Core-periphery brain network interactions fluctuate, influencing behavior and clinical symptoms.
Brain regions with shorter timescales (periphery) are linked to perception/movement, while longer timescales (core) relate to self-cognition/emotion.

Purpose of the Study:

To review evidence on atypical core-periphery brain dynamics in autism.
To characterize how these dynamics relate to sensory and cognitive profiles in autism.
To synthesize findings from time-resolved functional magnetic resonance imaging (fMRI) studies.

Main Methods:

Systematic review of time-resolved fMRI studies in autism.
Analysis of macroscale brain network dynamics and timescales.
Correlation of core-periphery dynamics with behavioral and cognitive phenotypes.

Main Results:

Autism is characterized by atypical core-periphery brain dynamics.
Specific patterns of timescale alterations in core and peripheral regions are observed.
These dynamics are associated with distinct sensory and cognitive profiles in individuals with autism.

Conclusions:

Core-periphery brain dynamics represent a crucial aspect of brain function in autism.
Understanding these dynamics offers insights into the neurobiological underpinnings of autism-related behaviors.
Time-resolved fMRI provides valuable tools for investigating brain network alterations in neurodevelopmental disorders.