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Sarcoidosis with multiple calcification.

T Ishizaki1, H Kuroda, T Kuroda

  • 1Third Department of Internal Medicine, Fukui Medical School, Japan.

Japanese Journal of Medicine
|May 1, 1988
PubMed
Summary
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This case report details a rare, long-term sarcoidosis case with widespread calcified deposits. Immunological factors likely drive the insidious progression of calcification in this patient.

Area of Science:

  • Immunology
  • Radiology
  • Pathology

Background:

  • Sarcoidosis is a multisystem inflammatory disease.
  • Widespread calcification is an uncommon manifestation of sarcoidosis.

Observation:

  • A patient presented with a 29-year clinical course of sarcoidosis.
  • Multiple calcified deposits were observed in the neck, mediastinum, liver, spleen, kidney, abdominal lymph nodes, and lungs.
  • Calcified opacities were initially detected within two years and showed insidious increase in size.

Findings:

  • The exact pathogenesis of the extensive calcification remained undetermined.
  • Evidence suggests that immunological derangement plays a role in initiating and promoting calcification in sarcoidosis.

Implications:

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  • This case highlights the diverse and progressive nature of sarcoidosis.
  • Further research into the immunological mechanisms of calcification in sarcoidosis is warranted.