Childhood dystonic reactions in the middle Black Sea region

Sevgi Çirakli1

  • 1Ordu University, Faculty of Medicine, Department of Pediatrics, Division of Pediatric, Neurology, Ordu, Turkey.

Medicine
|June 30, 2021
PubMed

Insights

Acute dystonic reactions in children are typically drug-induced and resolve quickly with prompt treatment. Early diagnosis and intervention with medications like biperiden are crucial for managing these neurological events.

Area of Science:

  • Pediatric Neurology
  • Clinical Pharmacology

Background:

  • Acute dystonic reactions are a significant cause of emergency department visits in children.
  • Rapid diagnosis and treatment are essential for managing these neurological events.

Purpose of the Study:

  • To investigate the clinical features, causes, and outcomes of acute dystonic reactions in pediatric patients.
  • To analyze the effectiveness of treatment in a tertiary pediatric neurology setting.

Main Methods:

  • Retrospective review of medical records for nine pediatric patients treated for acute dystonic reactions between May 2018 and May 2020.
  • Data collected included age, gender, etiology, family history, treatment, and patient outcomes.

Main Results:

  • All nine pediatric patients experienced drug-induced acute dystonic reactions, primarily from metoclopramide, risperidone, and aripiprazole.
  • Intramuscular biperiden administration resulted in dramatic improvement within 30 minutes for all patients, with only one requiring an additional dose.
  • All patients were discharged within 24 hours with no observed complications during follow-up.

Conclusions:

  • Drug-induced acute dystonic reactions in children are diagnosable and fully reversible with effective treatment.
  • Prompt administration of appropriate medication, such as biperiden, is key to successful management.
  • While treatable, the potential for severe clinical manifestations necessitates timely intervention.

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