Analysis of perinatal coagulation function in preeclampsia

Area of Science:

• Obstetrics and Gynecology
• Hematology
• Perinatal Medicine

Background:

• Preeclampsia (PE) is a serious pregnancy complication.
• Dynamic changes in coagulation function during the perinatal period in PE are not fully understood.
• Understanding these changes is crucial for managing PE-related risks.

Purpose of the Study:

• To investigate the dynamic changes in coagulation function in patients with preeclampsia (PE) during the perinatal period.
• To compare coagulation profiles of PE patients with healthy pregnant women.
• To identify coagulation patterns associated with increased risk of adverse outcomes in PE.

Main Methods:

• Prospective study involving 290 PE patients and 256 healthy pregnant women.
• Coagulation indexes including PT, APTT, TT, FIB, PLT, MPV, PCT, DD, FDP, and MA were measured.
• Data collected during the prenatal period and at 1 and 3 days postpartum.

Main Results:

• PE patients showed decreased PT, FIB, PLT, MPV, PCT, MA, and CI, with increased APTT, TT, DD, PDW, and K values pre-delivery compared to controls.
• Postpartum day 1 in PE patients revealed lower APTT and FIB, and higher TT, DD, and FDP compared to prenatal and postpartum day 3.
• PCT and MPV were highest prenatally in PE patients.

Conclusions:

• PE patients exhibit a state of relative hypocoagulation and hyperfibrinolysis on postpartum day 1.
• This altered coagulation state increases the risk of postpartum hemorrhage and other adverse outcomes.
• Dynamic monitoring of coagulation function is essential for managing PE patients.