Related Experiment Video

Updated: Oct 31, 2025

Noninvasive and Invasive Renal Hypoxia Monitoring in a Porcine Model of Hemorrhagic Shock
07:48

Noninvasive and Invasive Renal Hypoxia Monitoring in a Porcine Model of Hemorrhagic Shock

Published on: October 28, 2022

1.4K

C-reactive protein and haemoglobin level in acute kidney injury among preterm newborns

Fiva Aprilia Kadi1, Tetty Yuniati1, Yunia Sribudian1

  • 1Department of Child Health, Universitas Padjadjaran Medical School/Dr Hasan Sadikin General Hospital, Bandung, West Java, Indonesia.

Medicinski Glasnik : Official Publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina
|June 30, 2021
PubMed

Insights

C-reactive protein (CRP) and hemoglobin (Hb) can predict acute kidney injury (AKI) in preterm newborns. Elevated CRP and low Hb levels serve as an early warning for AKI risk.

Area of Science:

  • Neonatal Medicine
  • Biomarkers
  • Nephrology

Background:

  • Acute kidney injury (AKI) is a significant concern in preterm newborns.
  • Early detection and risk assessment of AKI are crucial for improving outcomes.
  • Biomarkers like C-reactive protein (CRP) and hemoglobin (Hb) are being investigated for their predictive potential.

Purpose of the Study:

  • To evaluate the role of C-reactive protein (CRP) and hemoglobin (Hb) in predicting and assessing the risk of acute kidney injury (AKI) in preterm infants.
  • To identify cost-effective methods for early AKI detection in neonates.

Main Methods:

  • A case-control study involving 112 preterm infants was conducted.
  • Infants were categorized into groups with and without AKI based on neonatal KDIGO criteria.
  • Serum CRP and creatinine levels were measured at specific intervals post-birth; routine blood counts including Hb were performed within 24 hours.

Main Results:

  • Increased C-reactive protein (CRP) was the most significant predictor of AKI, demonstrating 80.6% sensitivity and 60.2% specificity.
  • An elevated CRP level (>0.04) was associated with a 5.64-fold increased odds of AKI (aOR: 5.64, 95% CI: 1.89-16.84).
  • Hemoglobin (Hb) levels below 14.5 g/dL showed a slightly increased odds of AKI (aOR: 1.65, 95% CI: 1.05-8.63).

Conclusions:

  • Elevated CRP levels (>0.04) and low hemoglobin (<14.5 g/dL) are acceptable early warning indicators for AKI in preterm newborns.
  • These biomarkers offer a potential strategy for early risk assessment and intervention in neonatal AKI.

Keywords:
AKICRPanaemianeonatesrenal injury

More Related Videos

Modeling Neonatal Intraventricular Hemorrhage Through Intraventricular Injection of Hemoglobin07:57

Modeling Neonatal Intraventricular Hemorrhage Through Intraventricular Injection of Hemoglobin

Published on: August 25, 2022

3.2K
A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion09:02

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Published on: February 2, 2021

4.6K

Related Concept Videos

Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
106
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
212
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
427
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
281
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
356
Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
163