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Therapeutic results of laryngeal preservation: a retrospective study
W Ben Kridis1, I Werda1, W Mnejja1
1Habib Bourguiba Hospital, University of Sfax, 3029 Sfax, Tunisia.
Aim:
The objective of this study is to report the therapeutic results of the preservation strategy in locally advanced laryngeal cancers.
Patients And Methods:
Between January 2008 and December 2015, 24 patients with locoregional advanced non-metastatic laryngeal cancer (T2-4/N0-2) were collected retrospectively. Different therapeutic sequences were used: either induction chemotherapy followed by concurrent chemoradiotherapy or induction chemotherapy followed by radiotherapy or concurrent chemoradiotherapy or radiotherapy alone.
Results:
The objective response rate was 85.7%. Overall survival rates at 1 year, 3 years and 5 years were 91.3%, 80.2% and 53.5%, respectively. Administration of induction chemotherapy did not improve overall survival. The 1-year overall survival was 83.3% in the induction chemotherapy group vs 94.1% for those who did not received induction chemotherapy (p = 0.7).
Conclusion:
Our study showed the feasibility of this preservation strategy in clinical practice, with acceptable term toxicity.
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