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Updated: Oct 31, 2025

Porcine Model of Infrarenal Abdominal Aortic Aneurysm

Porcine Model of Infrarenal Abdominal Aortic Aneurysm

Published on: November 21, 2019

Thoracic aortic aneurysm. An experimental model in pigs.

Rodrigo Argenta¹, Sílvio César Perini¹, Adamastor Humberto Pereira²

¹MD. Postgraduate Program in Surgical Sciences - Medical Faculty - Universidade Federal do Rio Grande do Sul - Porto Alegre (RS), Brazil.

Acta Cirurgica Brasileira

|June 30, 2021

Summary

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Abdominal aortic aneurysm model in swine with bovine pericardium patch.

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This study presents a novel pig model for descending thoracic aortic aneurysms. The experimental model is stable, easy to perform, and mimics human degenerative aneurysms.

Area of Science:

Cardiovascular Research
Surgical Innovation
Animal Models

Background:

Descending thoracic aortic aneurysms (DTAA) pose significant clinical challenges.
Existing animal models may not fully replicate human DTAA pathology.
A reliable experimental model is crucial for studying DTAA pathogenesis and testing therapies.

Purpose of the Study:

To detail an innovative, unpublished experimental model for inducing descending thoracic aortic aneurysms in pigs.
To establish a reproducible preclinical platform for DTAA research.

Main Methods:

Ten Landrace pigs underwent thoracotomy to expose the descending thoracic aorta.
A bovine pericardium patch was sutured to create an aneurysm.
Three-week follow-up included aortography, followed by explantation and histological analysis.

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Author Spotlight: Development of a Minimally Invasive Large-Animal Model for Reliable and Reproducible Cardiovascular Research

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Published on: October 20, 2023

Murine Surgical Model of Topical Elastase Induced Descending Thoracic Aortic Aneurysm

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Published on: August 24, 2019

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Last Updated: Oct 31, 2025

Porcine Model of Infrarenal Abdominal Aortic Aneurysm

Porcine Model of Infrarenal Abdominal Aortic Aneurysm

Published on: November 21, 2019

Author Spotlight: Development of a Minimally Invasive Large-Animal Model for Reliable and Reproducible Cardiovascular Research

Author Spotlight: Development of a Minimally Invasive Large-Animal Model for Reliable and Reproducible Cardiovascular Research

Published on: October 20, 2023

Murine Surgical Model of Topical Elastase Induced Descending Thoracic Aortic Aneurysm

Murine Surgical Model of Topical Elastase Induced Descending Thoracic Aortic Aneurysm

Published on: August 24, 2019

Main Results:

All pigs survived the procedure with patent, stable aneurysms and intact suture lines.
Histology revealed significant adventitial reaction with myofibroblasts.
No complications or adverse effects on animal development were observed.

Conclusions:

The described pig model for DTAA is easily executed, safe, and yields stable aneurysms.
This model demonstrates characteristics similar to human degenerative aneurysms.
It offers a valuable tool for future DTAA research and therapeutic development.