Related Experiment Video
Updated: Oct 31, 2025
Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device
Published on: May 2, 2025
[Tumors of the central nervous system in children and adolescents]
1Bereich für Kinderradiologie, Institut und Poliklinik für diagnostische und interventionelle Radiologie, Universitätsklinikum Carl Gustav Carus, Fetscherstr. 74, 01307, Dresden, Deutschland. gabriele.hahn@uniklinikum-dresden.de.
Clinical/Methodological Issue:
Brain tumors are the most common solid tumors in childhood and the most frequent cancer after leukemia. The incidence is continuously increasing. The WHO classification of brain tumors, valid since 2016, is now based on the combination of histological and molecular genetic diagnostics.
Standard Radiological Methods:
Diagnostics are mainly performed with magnetic resonance imaging (MRI); only in emergencies with computed tomography (CT).
Methodological Innovations:
Diffusion and susceptibility weighted and dynamic contrast-enhanced imaging and spectroscopy are used.
Performance:
Improved diagnosis regarding dignity, size determination, adjacency assessment, and morphological description of tumor composition.
Achievements:
Modern MRI with functional techniques is now the gold standard for differential diagnosis and staging of central nervous system (CNS) tumors in pediatrics.
