Prioritizing studies of COVID-19 and lessons learned

Area of Science:

• Clinical and Translational Science
• Public Health Research
• Pandemic Preparedness

Background:

• COVID-19 significantly disrupted research activities within Clinical and Translational Science Award (CTSA) hubs.
• CTSA hubs demonstrated an unprecedented need to adjust research operations in response to the pandemic.

Purpose of the Study:

• To evaluate the impact of the CTSA network on the COVID-19 pandemic response.
• To assess CTSA involvement in decision-making regarding COVID-19 study prioritization and infrastructure development.

Main Methods:

• A survey was administered in October 2020 to CTSA members with assistance from the NIH survey team.
• Data from 60 of 64 CTSAs were analyzed using descriptive and statistical methods.
• Survey questions focused on CTSA involvement in prioritizing COVID-19 studies and resource allocation.

Main Results:

• Most CTSAs, despite initial unpreparedness, responded swiftly to the pandemic, enhancing engagement and establishing triage systems.
• CTSA involvement in decision-making increased the likelihood of creating dedicated diagnostic labs (16.75x) and securing internal funding for COVID-19 research (3.88x).
• CTSA facilitated funding, infrastructure development, modified workflows for contracting and IRB review, and established central committees for study prioritization.

Conclusions:

• CTSA hubs played a crucial role in prioritizing research and building essential infrastructure during the COVID-19 pandemic.
• Prompt, flexible research leadership with decision-making authority is vital for managing future pandemics effectively.