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Exploratory Study of the Effectiveness of Granulocyte and Monocyte Adsorptive Apheresis Before Initiation of Steroids
Kazuki Kakimoto1, Minoru Matsuura2, Takumi Fukuchi3
12nd Department of Internal Medicine, Osaka Medical College, Takatsuki, Osaka, Japan.
Background:
Granulocyte and monocyte adsorptive apheresis (GMA) has been used for therapy of steroid-dependent/refractory ulcerative colitis (UC). The aim of this study was to investigate the effectiveness of GMA in UC patients not receiving steroids.
Methods:
We conducted a single-arm, open-label, and multicenter prospective clinical trial. UC patients who had insufficient responses to 5-aminosalicylic acid received GMA twice a week for 5 weeks.
Results:
The response rate of all patients was 58.2% (39/67). Of the 39 patients who achieved a response, 74.4% achieved endoscopically confirmed mucosal healing.
Conclusions:
GMA shows effectiveness in inducing remission in UC patients not receiving steroid.
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