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Related Experiment Videos

An oral zinc loading test in psoriasis.

N Linder1, M Statter, V Leibovici

  • 1Department of Pediatrics, Hadassah University Hospital, Jerusalem, Israel.

Metabolism: Clinical and Experimental
|September 1, 1988
PubMed
Summary

Patients with extensive psoriasis show lower peak plasma zinc levels after oral zinc loading compared to healthy individuals. This suggests impaired zinc absorption or altered zinc metabolism in psoriasis.

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Area of Science:

  • Dermatology
  • Nutritional Science
  • Biochemistry

Background:

  • Psoriasis is a chronic inflammatory skin condition.
  • Zinc is an essential mineral involved in numerous biological processes, including immune function and skin health.
  • Alterations in zinc levels have been suggested in various skin diseases, including psoriasis.

Purpose of the Study:

  • To investigate zinc metabolism in patients with extensive psoriasis.
  • To compare plasma zinc levels and urinary zinc excretion after an oral zinc load in psoriatic patients versus healthy controls.

Main Methods:

  • An oral zinc loading test was administered to 12 patients with extensive psoriasis and 11 healthy volunteers.
  • Plasma zinc concentrations and urinary zinc excretion were measured.

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  • Measurements were taken after an overnight fast and at intervals following zinc ingestion.
  • Atomic absorption spectrophotometry was used for quantitative analysis.

    • Main Results:

    • No significant differences in fasting plasma zinc or urinary zinc excretion were observed between groups.
    • Both psoriatic patients and controls exhibited increased urinary zinc excretion post-loading.
    • Significantly lower peak plasma zinc levels were recorded in psoriatic patients at 2 and 4 hours after zinc ingestion (P < .01 and P < .02, respectively).

    Conclusions:

    • Patients with extensive psoriasis may have impaired plasma zinc uptake or altered zinc distribution following oral zinc supplementation.
    • These findings suggest a potential role for zinc dysregulation in the pathophysiology of psoriasis.
    • Further research is warranted to explore the clinical implications of zinc metabolism alterations in psoriasis management.